Based on the number of DEGs, the top signaling pathways differentially regulated in the astrocytes of AD patients in the context of neurodegeneration include Alzheimer’s disease, prion disease, Parkinson’s disease, Huntington’s disease, neurodegeneration signaling pathways (multiple diseases), amyotrophic lateral sclerosis, and the phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT) pathway. This evidence concerns the gene AKT1 and early-onset autosomal dominant Alzheimer disease.