The most downregulated GWAS genes in astrocytes from the entorhinal cortex associated with the pathogenesis of AD were NKAIN3, LRRC4C, CADM2, DLC1, APOE, TNIK, GADD45G, FRMD4A, CTNNA2, NPAS3, NCKAP5, and RORA. This evidence concerns the gene DLC1 and Alzheimer disease.