The most downregulated GWAS genes in astrocytes from the entorhinal cortex associated with the pathogenesis of AD were NKAIN3, LRRC4C, CADM2, DLC1, APOE, TNIK, GADD45G, FRMD4A, CTNNA2, NPAS3, NCKAP5, and RORA. Here, NPAS3 is linked to Alzheimer disease.