AKT1 and prion disease: Based on the number of DEGs, the top signaling pathways differentially regulated in the astrocytes of AD patients in the context of neurodegeneration include Alzheimer’s disease, prion disease, Parkinson’s disease, Huntington’s disease, neurodegeneration signaling pathways (multiple diseases), amyotrophic lateral sclerosis, and the phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT) pathway.