At the same time, flow cytometry and ELISA documented that the WT mice and miR-21+/+ mice following radiotherapy exhibited increased numbers of CD3+CD8+ positive cells and IL-2 and IFN-γ levels and decreased T lymphocyte apoptosis rate in peripheral blood and tumor tissues as compared with the miR-21+/+ mice without treatment. This evidence concerns the gene CD8A and neoplasm.