Experimental models of post-inflammatory IBS have revealed that previous inflammatory insult in the colon of rodents sensitizes afferent neurons to induce visceral hypersensitivity mediated by increased expression of nociceptive receptors including calcitonin gene-related peptide (CGRP) (35) and transient receptor potential cation channel subfamily V member 1 (TrpV1) (36) in the dorsal root ganglia cells (37, 38) leading to enhanced nociceptive transmission. Here, TRPV1 is linked to irritable bowel syndrome.