In light of increased endothelial cell survival and vascular integrity conferred by HGF/IgG after MI/R (Rao et al., 2015), we tested FGF2/IgG in cell protection assays with primary human cardiac microvascular endothelial cells under culture conditions that simulated ischemia (nutrient deprivation and 1% oxygen). The gene discussed is FGF2; the disease is myocardial infarction.