Many studies reported various biological targets plays a vital role in cancer progression, one of the major biomarkers is human galectin-1 protein, which is highly expressed in multiple cancers (99, 100), and therefore, which could be the potential targets for novel PET radiotracers to image various conditions in cancer, here a few examples of human galectin-1 selective inhibitors where they have been successfully labeled with fluorine-18 and proved to be PET imaging agents for the diagnosis of cancer (101, 102). The gene discussed is LGALS1; the disease is cancer.