Yu et al. (60) demonstrated that molecular hydrogen may be a promising agent for alleviating SAE and that 2% H2 inhalation can protect against sepsis-induced neuroinflammation by decreasing DNMT1- and DNMT3a-mediated BDNF promoter IV methylation, enhancing BDNF levels and improving the cognitive dysfunction in septic mice. The gene discussed is DNMT3A; the disease is Sepsis.