TRPM8 and neoplasm: Furthermore, other subtypes in the TRPs family were reported to be involved in regulating tumor-induced nociceptive pain, such as transient receptor potential vanilloid 1 (TRPV1), transient receptor potential vanilloid 3 (TRPV3), transient receptor potential vanilloid 4 (TRPV4), and transient receptor potential melastatin 8 (TRPM8) [35, 38].