KEGG analysis revealed that the six hub targets were mainly associated with immune system (C-type lectin receptor (CLR) signaling pathway, Toll-like receptor (TLR) signaling pathway, IL-17 signaling pathway and Fc epsilon RI signaling pathway), signal transduction (TNF signaling pathway and VEGF signaling pathway) and infectious disease (Figure 3D). Here, CLEC4D is linked to infectious disease.