Interestingly, 2 days after i.v. injection of cancer cells, upregulation of Ang-2 (Figure 4B) and the soluble form of its receptor Tie-2 (Figure 4C) were detectable in the plasma, while the concentration of sFlt-1 in the plasma was not increased (Figure 4D), indicating that, in contrast to Ang-2-dependent pathway, VEGF-dependent signalling might be not involved in the negative effects of dabigatran in 4T1 breast cancer cell-injected mice. The gene discussed is ANGPT2; the disease is breast carcinoma.