MMP9 and cancer: The higher lung permeability 24 h after i.v. injection in dabigatran-treated and 4T1 cancer cell-injected mice was followed by increased breast cancer cell extravasation and settlement in the lungs 2 days after injection (Figure 1A) that was associated with an increased inflammatory response in the lungs of dabigatran-treated mice (Angiopoietin-2 (Ang-2), Figure 3B; E-selectin, Figure 3C; and matrix metalloproteinase 9 (MMP-9), Figure 3D).