PROS1 and acute disseminated encephalomyelitis: Inactivated vaccines against SARS-CoV, MERS-CoV and recombinant vaccines based on SARS-CoV full-length S protein induced ADE and caused lung pathology, and this stopped their further application (Jaume et al., 2012; Tseng et al., 2012; Agrawal et al., 2016; Wang et al., 2016).