Additionally, Geng et al. investigated the expression of miR-18a-5p in human aortic valvular endothelial cells and found the overexpression of miR-18a-5p could down-regulate Notch2 expression and subsequently suppress endothelial–mesenchymal transition, to inhibit myocardial fibrosis (26). The gene discussed is NOTCH2; the disease is Myocardial fibrosis.