For example, in the gene set associated with the development of the central nervous system, processes and abnormalities such as neuron migration, regulation of neurotransmitter levels, in utero embryonic development, neoplasm of central nervous system, neoplasm of the nervous system and morphological abnormalities of the central nervous system were among the top overrepresented, which supports the conclusion that the associated DARS gene set is indeed very relevant. Here, DARS1 is linked to nervous system neoplasm.