The PDGF/PDGFR system has shown its immense role in the development and progression of RA disease as follows: several pieces of research on the PDGF/PDGFR system in tissues of RA patients and in vitro and in vivo studies have demonstrated the system's significant role in the occurrence, development, and progression of RA. The gene discussed is PDGFRB; the disease is rheumatoid arthritis.