While mutations in Dcc, Csmd3, and Fhit are rather uncommon in human lung adenocarcinomas, deletions or allelic imbalances occur frequently and are considered early events in human lung tumorigenesis (Sozzi et al., 1998; Kohno et al., 2000; Ma et al., 2009; Ahn et al., 2014; Cancer Genome Atlas Research Network, 2014). The gene discussed is DCC; the disease is lung adenocarcinoma.