In fact, Donoso et al. (2020) recently demonstrated that an 8-week xanthohumol (0.015%; 10 mg/kg/day) supplementation period in adult rats exposed to early life stress (3 h daily maternal separation from PND 2–12) reduced basal and stress-induced CORT secretion and reduced anxiety-like behaviors observed in non-supplemented rats. Here, CORT is linked to Anxiety.