In this context, upregulation of basal and stress-induced corticosterone (CORT) levels has been observed following gestational and lactational low-dose BPA exposure (40 μg/kg/day) in male rats (Panagiotidou et al., 2014) while perinatal and adult low- and high-dose exposure increased anxiety and depressive-like behavior (Matsuda et al., 2012; Chen et al., 2014; Xu et al., 2015). The gene discussed is CORT; the disease is Anxiety.