CFTR and cystic fibrosis: This phenomenon is well known not only from studies in models of cystic fibrosis and acquired CFTR deficiency—even though the exact mechanism of the interaction between these two channels remains to be elucidated (Tarran et al., 2001; Boucher, 2003; Zhang et al., 2013; Hassan et al., 2014; Rasmussen et al., 2014; Woodworth, 2015; Raju et al., 2016)—but also from studies with pharmacological agents that enhance CFTR expression and/or function or perturb the interaction between CFTR and ENaC (Van Goor et al., 2009; Van Goor et al., 2011; Lambert et al., 2014).