Orexin A (OX-A) and orexin B(OX-B) are the hypothalamic neuropeptides which are known as importantregulators of sleep/wakefulness states.1,2 Loss of orexinergicneurons in the brain is associated with the cause of narcolepsy type1 (NT1) characterized by excessive daytime sleepiness, cataplexy,hypnagogic/hypnopompic hallucinations, sleep paralysis, and disturbednighttime sleep.3−6. The gene discussed is HCRT; the disease is Cataplexy.