Previous studies have shown that representative neuroinflammation is associated with postoperative cognitive impairment, and the clinical study in this study showed that postoperative peripheral blood MAGI-2 and TLR4/NF-κB signaling pathway were higher in delirium than in non-delirium patients, and animal experiment in this study further revealed the relationship between the TLR4/NF-κB signaling pathway and MAGI-2. Here, MAGI2 is linked to Cognitive impairment.