IL1B and infection: In DSS- and infection-induced mouse models of colitis, dysregulated IL-1β and/or its receptor signaling also promoted exacerbated tissue inflammation (Maeda et al., 2005; Muller et al., 2009; Neudecker et al., 2017; Ng et al., 2010; Saitoh et al., 2008; Seo et al., 2015).