Nonetheless, we were intrigued about the augmented levels of Il17a and Il1r1 transcripts found in cluster 3 RORγtS182A colonic Th17 cells (Figures 1H and 1I), as the elevated IL-1β level was associated with increased disease severity in patients with inflammatory bowel diseases (Coccia et al., 2012; Ligumsky et al., 1990). This evidence concerns the gene IL1R1 and inflammatory bowel disease.