This translocation leads to the fusion of two transcription factors involved in normal hematopoiesis, ETV6 and RUNX1. Although the ETV6-RUNX1 translocation has been detected in a large number of healthy neonates (1-5%), leukemia incidence among carriers is much lower (0.2–1%) [3, 43]. This evidence concerns the gene RUNX1 and leukemia.