EEF2K and neoplasm: This analysis revealed the significance of miRNA-22-eEF2K interaction, eEF2K-tumor growth feedback loop, tumor vascularization, miRNA-22 potency and stability, NP characteristics, and also the immune checkpoint effects of PD-L1, which highlights the potential of miRNA-22 used in combination with anti-PD-L1 therapy to improve %TGI.