Different cardiac biomarkers, including cardiac troponin I (cTnI), alpha-hydroxybutyrate dehydrogenase (α-HBDH), myoglobin (Mb), lactate dehydrogenase (LDH), creatine phosphokinase (CPK), creatinine phosphokinase-muscle/brain (CPK-MB), aspartate aminotransferase (AST), and brain natriuretic peptide (BNP)/N-terminal of the prohormone brain natriuretic peptide (NT-proBNP), increase to a different extent among patients with Coronavirus disease of 2019 (COVID-19). This evidence concerns the gene PIK3C2A and COVID-19.