We have previously demonstrated that following glycerol treatment, in a RM-AKI rat model, nuclear Bach1 levels rapidly and significantly decreased 3 h after treatment, which was preceded by the induction of HO-1 mRNA expression, suggesting that nuclear Bach1 was displaced from MARE and exported from the nucleus by directly binding to heme released from myoglobin, ultimately leading to HO-1 induction [11]. Here, MB is linked to acute kidney injury.