Results of qPCR tests and Western blots revealed that compared with neuroma cell culture without the HuD antibody, the expression levels of M1 macrophage-inducible factors TNF-α, IL-12, INF-γ, and TGF-β increased in the presence of the HuD antibody, and the expression levels of M2 macrophage-inducible factors IL-10, IL-4, and Arg-1 decreased. The gene discussed is ARG1; the disease is neuroma.