In humans, heterozygous variants in CACNA2D1 have previously been associated with inherited arrhythmogenic disease, including Brugada25 and short QT26 syndromes, as well as infantile spasms27 and intellectual disability and epilepsy.28 Re-evaluation of these monoallelic variants, together with genetic data presented here give rise to reasonable doubt about an association of these CACNA2D1 variants with disease (Supplementary material). Here, CACNA2D1 is linked to Intellectual disability.