ATXN2L and Cerebellar atrophy: However, atrophy of the brain affects the cerebrum in the two affected individuals with CACNA2D1 variants, whereas cerebellar atrophy was consistently reported in subjects with CACNA2D2 variants.29 These data indicate that loss of α2δ-1 or α2δ-2 cannot be compensated by any of the other α2δ subunits during development.