This reflects the strong expression of α2δ-2 in particular neurons, specifically cerebellar Purkinje cells.7 In humans, biallelic CACNA2D2 variants cause a phenotypic spectrum ranging from congenital ataxia with cerebellar vermian atrophy on brain imaging8 to cerebellar atrophy and developmental and epileptic encephalopathies (DEEs).9,10 DEEs are characterized by intractable seizures and developmental impairment or regression.11 This evidence concerns the gene CACNA2D2 and Cerebellar atrophy.