We observed decreased protein expression of SRD5A2 in advanced tumor stages (Gleason ≤ 7 vs. Gleason >7, P = 0.031, Stage I + II vs. Stage III + IV, P = 0.148, Gleason 3 + 4 vs. Gleason 4 + 3, P = 0.035, Fig. 4a). Here, SRD5A2 is linked to neoplasm.