We chose SRD5A2 and ITGA11 for further validation, due to the high weight of these two genes in the risk score formula, 1.20428 for ITGA11 and 0.71137 for SRD5A2. What’s more, several studies reported the association between SRD5A2 polymorphism and PCa risk, while rarely study reported the function of ITGA11 in PCa, therefore, we final chose these two genes for experimental validation. This evidence concerns the gene SRD5A2 and posterior cortical atrophy.