TNF and cancer: Genes uniquely upregulated in KFs/KFc were related to homologous recombination and cell cycle, with pathways including several histone genes (Alcoholism, Systemic lupus erythematosus, Figure 7—figure supplement 1a); those selectively upregulated in HFs/HFc were associated with cell migration (axon guidance), vasopressin regulated water absorption and lipid metabolism; and to proinflammatory pathways for TFs/TFc (TNF signaling, cytokine–receptor interactions, pathways in cancers) (Figure 7l).