Despite the strong associations with decreased testosterone levels and neurodegenerative disease, the impact of ATT and risk of neurodegenerative diseases,39 including Alzheimer's disease (AD)21, 30 Multiple sclerosis (MS),40 Parkinson's disease (PD),41, 42 and Amyotrophic Lateral Sclerosis (ALS),43, 44 remain controversial with few studies reporting the association with androgen receptor and synthesis inhibitors. This evidence concerns the gene AR and neurodegenerative disease.