AR and amyotrophic lateral sclerosis: For ALS, abiraterone (RR, 4.46; 95% CI, 2.40–8.27; p < 0.001) and androgen receptor inhibitors (RR, 8.40; 95% CI, 4.50–15.60; p < 0.001) were associated with a significantly increased risk of ALS (Figure 2).