Consistent with these results in the injury‐induced ASC mouse model, we also observed that in the lens epithelium of human ASC patients, AKT S473 and EZH2 S21 phosphorylation are significantly upregulated (Figure 1C–E and Figure S1, Supporting Information), and the expression level of H2K27me3 was downregulated but the expression levels of fibronectin and α‐SMA was greatly upregulated (Figure 1C–E, and Figure S1, Supporting Information). Here, FN1 is linked to Tako-tsubo cardiomyopathy.