In the present study, we explored the predictivevalue of DNA repair gene expression for response to NACT in BC by evaluating themRNA expression of 11 selected genes that have a key role in DNA repair mechanisms.In addition, BRCA1, BRCA2, RAD51C, ATM, and PALB2are tightly correlated with breast cancer and have been associated with breastcancer predisposition, clinicopathological features, and prognosis (11). This evidence concerns the gene BRCA1 and breast cancer.