For example, Algate’s, as many other studies, showed TNF-α playing a potent catabolic role by stimulating osteoclastic bone resorption and the suppression of osteoblastic bone formation.6 In a study of a periodontitis model, Apolinario and Pereira showed that IL-1 contributed to alveolar bone resorption and attachment loss, which was reduced by inhibiting IL-1 activity.26 , 27. The gene discussed is TNF; the disease is periodontitis.