For example, EGR1 (rank1st) was involved in regulating PMA-induced megakaryocytic differentiation of K562 cell line [31]; the inhibition of E2F7 (rank3rd) might lead to a reduction of miRNAs involved in leukemic cell lines [32]; the expression of JunB (rank5th) was inactivated by methylation in chronic myeloid leukemia [33]. The gene discussed is EGR1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.