Of the top 10 canonical pathways identified, six were related to inflammation signalling (IL‐10, IL‐6, role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis, Toll‐like receptor, HMGB1and NF‐κB), two to growth signalling (cardiac hypertrophy and Gβγ), one to metabolism (PPAR) and one difficult to identify in muscle signalling (hepatic cholestasis). This evidence concerns the gene IL10 and rheumatoid arthritis.