Consistent with intercellular communication of intracellular muscle status, the majority of pathways (6 of 10) targeted by muscle small EV miRNAs and altered by concurrent exercise training were related to inflammation signalling: IL‐10, IL‐6, role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis, Toll‐like receptor, HMGB1 and NF‐κB. Here, HMGB1 is linked to rheumatoid arthritis.