Both methodologies can yield quantitative information about c‐Met expression, but they have critical limitations: they are not able to reflect the c‐Met expression variation over time, they cannot deal with the receptor heterogeneity in different tumor sites, biopsies cannot be conducted on inaccessible sites, and they provide only a small sample of heterogeneous tissue within a single tumor, in addition to the fact that recurring biopsies can be hurtful and difficult for the patient. Here, MET is linked to neoplasm.