HGF and neoplasm: The tumor uptake reached a peak between 10 and 17 min, the tumor/muscle ratio of radioactivity—contrast index—showed accumulation of the tracer in HGF positive tumors with high selectivity (5.74 tumor/muscle ratio of radioactivity for HGF−, 20.16 tumor/muscle ratio of radioactivity for HGF+), demonstrating that 64Cu‐HiP‐8‐PEG11 is an outstanding probe for noninvasive imaging of HGF–Met status in tumors on an animal model by PET imaging.