Studies have shown that IFN-β interferes with the accumulation of neutrophils by suppressing the expression of the C-X-C motif chemokine receptors, CXCR2 and CXCR4, and by blocking their ligands, CXCL1, CXCL2, or CXCL12, in tumor cells [55, 56]. This evidence concerns the gene IFNB1 and neoplasm.