In solid tumors and tumor-draining lymph nodes, emerging evidence indicates that the invading host cells involved in the production of the majority of cellular IFN-β are tumor-infiltrating CD11b+DCs, and that the binding of tumor-derived DNA to cytosolic DNA receptors serves as the likely trigger for the activation of tumor-infiltrating DCs [17–19]. This evidence concerns the gene IFNB1 and neoplasm.