STING1 and neoplasm: The nucleoside analog 6-thio-2’-deoxyguanosine (6-thio-dG), which induces damage to telomeric DNA in telomerase-expressing tumor cells to initiate the host cytosolic DNA-sensing type I IFNs/STING pathway, was reported to overcome ICB resistance in advanced tumors and was used in combination with ICBs in tumor models [165].