Colocalization analysis of circulating protein levels and risk of AF at the protein coding region further suggested that DUSP13, SPON1 and TNFSF12 had strong evidence of sharing a common causal variant [posterior probability (PP) of H4 ≥98%], and there was moderate evidence for IL-6R (PP of H4 = 59%) (Figure 5B;, Supplementary Figure S3 and Supplementary Table S4, available as Supplementary data at IJE online). Here, IL6R is linked to atrial fibrillation.