Hence, we delivered synthetic Ψ-modified mTOG and SCR oligos to HSPCs isolated from four distinct patients with HR-MDS and MDS-derived sAML, all characterized by low levels of mTOG and PUS7, and four healthy controls (HC; Fig. 3c, Extended Data Fig. 6a–e and Supplementary Table 7). Here, PUS7 is linked to myelodysplastic syndrome.