PUS7 and myelodysplastic syndrome: Dysregulation of PUS7 and mTOG leads to aberrant protein synthesis and impaired haematopoietic differentiation, and may have implications for the pathogenesis of high-risk MDS (HR-MDS) subtypes with chromosome 7 aberrations, including monosomy 7 (−7) or del(7q), that exhibit PUS7 loss-of-heterozygosity and a high risk of leukaemic transformation2,26.