GSDME and neoplasm: Using the Gene Expression Profiling Interactive Analysis (GEPIA) database (http://gepia.cancer-pku.cn/), we analysed PDAC tumour tissues (n = 179) and the adjacent tissues (n = 171), and found that GSDME, YBX1, MUC1 and MUC13 mRNAs are expressed at high levels in tumour tissues compared to the adjacent tissues (Fig. 6a and Extended Data Fig. 6a).