In addition, although GSDME−/− tumour cells lost the resistance to digestive enzymes, re-expression of exogenous MUC1 or MUC13 largely restored their resistance (Fig. 3c and Extended Data Fig. 3h), and the co-expression of MUC1 and MUC13 achieved the greatest resistance (Extended Data Fig. 3i). The gene discussed is MUC1; the disease is neoplasm.