Recently, a retrospective study analysed a cohort of EGFR-mutant NSCLC patients with multiple brain metastasis who received either EGFR-TKI plus bevacizumab or single-agent EGFR-TKI where significant PFS and OS benefits were both observed in the EGFR-TKI plus bevacizumab arm30. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.