PCOS ovaries exhibit higher vascularization and lower impedance to flow in ovarian stromal vessels compared to control85–87, which may be arisen from the differences in the levels of ovarian angiogenesis regulation factors as PCOS women showed higher VEGF levels and lower sVEGFR-1 levels compared to control both in serum and follicular fluid samples88,89. The gene discussed is VEGFA; the disease is polycystic ovary syndrome.