In addition, Vrtačnik-Bokal et al. study49 reported lower estradiol and vascular endothelial growth factors (VEGF) levels in the follicular fluids (FF) of PCOS women treated with the GnRH antagonist protocol compared to those treated with the Long GnRH agonist protocol. The gene discussed is GNRH1; the disease is polycystic ovary syndrome.