In a genome-wide methylation association study, after adjusting for white blood cell composition, methylation levels at four CpG sites (cg17150809, cg13033858, cg16936953, and cg18608055) were associated with circulating GDF-15 levels in discovery and validation populations and were potentially associated with prior myocardial infarction history7. The gene discussed is GDF15; the disease is myocardial infarction.