ESR1 and triple-negative breast carcinoma: Many clinical predictors for recurrence, including ER-negative, PR-negative, human epidermal growth factor receptor 2 (HER-2)-positive, triple-negative breast cancers, age, race, menopausal status, smoking, mammographic features, tumor morphology, tumor size, tumor stage, lymph node metastases, and gene expression profiling, have been proposed17,18.