Many clinical predictors for recurrence, including ER-negative, PR-negative, human epidermal growth factor receptor 2 (HER-2)-positive, triple-negative breast cancers, age, race, menopausal status, smoking, mammographic features, tumor morphology, tumor size, tumor stage, lymph node metastases, and gene expression profiling, have been proposed17,18. This evidence concerns the gene ERBB2 and neoplasm.