TNF and amyotrophic lateral sclerosis: These results seemed in accordance with violacein neuro-immunomodulatory and anti-inflammatory properties22,30, including the reduction of systemic levels of the inflammatory cytokines TNF-α, IL-1β and IL6, as well as the inhibition of MMP-2 and -930,31 that are elevated in limb muscles and spinal cord from hSOD1G93A ALS models and patients58, this protecting motor neurons and modulating inflammation32,33.