Statistical analysis of the differences in PC1 within each individual source exhibited significant differences in PC1 values between healthy and IBD cases from the same source in 3 of 4 sources (MITB, P < 0.01; MITCL, P < 0.001; MITA, P < 0.05; MITNE, P = 0.6) (Fig. 3B). This evidence concerns the gene STING1 and irritable bowel syndrome.