In turn, for coldspot regions with lowest 18F-PI-2620 PET binding, higher seed-based functional connectivity was associated with lower subcortical 18F-PI-2620 PET binding in strongly connected regions in PSP-RS (Fig. 5, β = −0.613, p < 0.001) and CBS (Fig. 5D, β = −0.617, p < 0.001), controlling for between-ROI Euclidean distance. The gene discussed is CBS; the disease is supranuclear palsy, progressive, 1.