Importantly, however, 18F-PI-2620 PET patterns in PSP-RS and CBS groups matched the tau patterns that are typically observed in histopathological assessments7, 8, and subcortical 18F-PI-2620 PET was significantly higher relative to controls, thus supporting the view that the 18F-PI-2620 PET signal in these 4 R tau predilection sites reflects no off-target signal but an increase in tau pathology27. Here, MAPT is linked to supranuclear palsy, progressive, 1.