We determined the covariance in inter-regional 18F-PI-2620 PET binding within CBS and PSP-RS groups, defined as partial correlation of ROI-based 18F-PI-2620 PET SUVRs, accounting for age, sex, and imaging site as confounds (methods illustrated in Fig. 3A, for subcortical tau covariance matrices see Fig. 3B for PSP-RS and Fig. 3C for CBS). The gene discussed is CBS; the disease is supranuclear palsy, progressive, 1.