When extending this analysis to the cortex, we found a similar result pattern, with highest 18F-PI-2620 PET binding in those cortical regions that were most closely connected to subcortical tau epicenters (i.e., Q1) vs. lowest 18F-PI-2620 PET binding in those cortical regions that were most weakly connected to subcortical tau epicenters (i.e., Q4) in PSP-RS (Fig. 6C, b/SE = 0.036/0.008, p < 0.001) and CBS (Fig. 6E, b/SE = 0.032/0.005, p < 0.001). Here, CBS is linked to supranuclear palsy, progressive, 1.