For neuropathological validation of the tau-PET data, we included regional postmortem tau assessments from two independent samples (Munich-European consortium/collection sample, n = 97; UPENN sample, n = 96) with histopathologically confirmed PSP, defined as the presence of neurofibrillary tau tangles (NFT) in the subthalamic nucleus, substantia nigra, and globus pallidus together with tufted astrocytes in the striatum and frontal cortex3, 8. Here, MAPT is linked to supranuclear palsy, progressive, 1.