MAPT and Classical progressive supranuclear palsy: Postmortem studies have reported a strong clinico-pathological correlation between 4R-tau deposition patterns and clinical phenotype: PSP most commonly presents as Richardson’s syndrome (PSP-RS, i.e., a combination of postural instability and ocular motor deficits), associated with brainstem and subcortical tau followed by progressive tau accumulation in parietal and motor cortices at later disease stages7, 8.