MAPT and early-onset autosomal dominant Alzheimer disease: For functional connectivity, we included resting-state fMRI data of 69 cognitively normal subjects from the Alzheimer’s disease neuroimaging initiative (ADNI, age = 67.89 ± 5.88, sex[f/m] = 39/30) cohort without evidence of amyloid or tau pathology as indicated by 18F-florbetapir amyloid-PET and 18F-flortaucipir tau-PET29, 30.