We found that for epicenter regions with highest 18F-PI-2620 PET binding, higher seed-based functional connectivity was associated with higher tau-PET binding in strongly connected subcortical regions in both PSP-RS (Fig. 5A, β = 0.880, p < 0.001) and CBS (Fig. 5B, β = 0.933, p < 0.001), controlling for between-ROI Euclidean Distance. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.