Genomic alterations in genes of the mitogen-activated protein kinase (MAPK) pathway, or activation of receptor tyrosine kinases (RTK), induce constant activation of MEK-ERK signaling, which regulates cell proliferation, survival, migration, and transformation.1 2 Since hyperactivation of the MAPK pathway is involved in the pathogenesis of head and neck cancer (HNC)3 4, 5, blockade of the MAPK pathway has been studied as a therapeutic approach for counteracting HNC progression. Here, WNK2 is linked to head and neck cancer.