PKM and hepatocellular carcinoma: We show that the acetylation level of H3K9 in the CDH1 promoter decreased when Flag-PPP1R26 was ectopically expressed in HCC cells (Fig. 7C), demonstrating that PPP1R26 forms a complex with PKM2 and TGIF2 to loosen TGIF2-CDH1 promoter binding, leading to suppression of CDH1 transcription.