PKM and hepatocellular carcinoma: We further show that overexpressed PPP1R26 forms a PPP1R26-pSer37-PKM2-TGIF2 complex to inhibit the binding of TGIF2 with CDH1 promoter, and the H3 acetylation level in the CDH1 promoter decreased, leading to transcriptional repression of CDH1. These results are consistent with PPP1R26 up-regulation promoting metastasis and progression in HCC patients.