In esophageal squamous cell carcinoma, a distinct model was proposed, in which, the lncRNA LUCAT1 binds DNMT1 to protect it from ubiquitination, while LUCAT1 knock-down promotes ubiquitination of DNMT1 through UHRF1 (Ubiquitin-Like PHD and RING Finger Domain-Containing Protein 1) [70]. The gene discussed is UHRF1; the disease is esophageal squamous cell carcinoma.