MAT2A and hepatocellular carcinoma: It was reported that the oncogenic lncRNA SNHG6 upregulates MAT2A expression as a competitive endogenous RNA (ceRNA) to sponge miR-1297, while down-regulates MAT1A translation by suppressing nucleocytoplasmic shuttling of MAT1A mRNA, thereby causing genome-wide hypomethylation and promoting HCC [88].