It was reported by several groups that lncRNAs serve as a protein-binding scaffold and induce ubiquitin-mediated DNMT protein degradation, epigenetically regulating target gene expression in obesity-mediated beta cell dysfunction [119], polycystic ovary syndrome [120] and hepatocellular carcinoma (HCC) [69]. This evidence concerns the gene DNMT1 and hepatocellular carcinoma.