PDCD1 and neoplasm: Similarly, a recent study on 23 deficient MisMatch Repair (dMMR)/microsatellite instability-high (MSI-High) patients observed that serial circulating tumor DNA (ctDNA) monitoring during Programmed cell death protein 1 (PD-1) blockade/progression was able to predict responses weeks ahead of standard imaging indicating that changes in ctDNA can help predict early tumor response to immunotherapy [149].