As an example, the previously characterized cardiometabolic risk gene FAM13A [25] not only colocalizes in subcutaneous adipose tissue with fasting insulin, T2D, WHR, TG, and HDL, but it also has second-order PPI interactions with 10 known IR/T2D genes and is differentially expressed under both glucose and insulin stimuli. The gene discussed is INS; the disease is type 2 diabetes mellitus.