MST1 and type 2 diabetes mellitus: For example, a locus on chromosome 3 spanning 2.5 Mb contained not only a T2D-associated variant in an intron that colocalized with RBM6, but also a fasting glucose variant, located 500 kb upstream of the RBM6-associated variant, regulating MST1 expression and splicing (Additional file 1: Fig. S4).