Specifically, we perform a custom colocalization analysis on twelve publicly available GWAS comprising nine different IR and cardiometabolic traits (fasting insulin, fasting glucose, insulin sensitivity, insulin sensitivity index, T2D, TG, HDL, BMI, and WHR) and expression and splicing quantitative trait loci (eQTLs and sQTLs) detected in five metabolically relevant tissues that directly impact glucose homeostasis: subcutaneous adipose and visceral adipose tissue, liver, skeletal muscle, and pancreas. The gene discussed is INS; the disease is type 2 diabetes mellitus.