PLEKHA1 and type 2 diabetes mellitus: Our list is supported by colocalization of genes known to lead to Mendelian forms of diabetes (e.g., SLC2A2 and WFS1) [64, 65] and of genes with previously demonstrated mechanisms of association with IR/T2D (e.g., METAP2, PLEKHA1 [TAPP1], FAM13A, and KLF14) [54, 57, 66, 67].