Similarly, another gene, PDGFC, which has been studied in the context of angiogenesis [62] and vascular diseases [63] but not yet extensively within IR/T2D, colocalizes in the same tissue (subcutaneous adipose) with all the same traits as FAM13A, although its direction of effect is opposite to FAM13A. PDGFC also responds to glucose and insulin stimuli and interacts with six known IR/T2D genes, two of which also interact with FAM13A (CAV1 and ZMPSTE24). This evidence concerns the gene INS and type 2 diabetes mellitus.